Better by design.
Diaphragm Valves · Pinch Valves · Sampling Valves · Stainless Fabrication
American made. Quality engineered. Industry trusted for thirty years.
The catalogue
The Aquasyn Difference
Aquasyn exists to eliminate compromise in hygienic-process components. That compromise has two sources, both invisible at procurement and both expensive when they surface in the field.
Design compromise
Most "hygienic" components are industrial parts adapted for high-purity service. The adaptations hide flaws in geometry, materials, and finish.
Surfaces as: contamination events, dead-leg residue, validation failures, premature wear, audit exposure.
Build compromise
Even when the design is right, broad-line manufacturers produce inconsistently. A part meets spec on paper but a different one fails in the field.
Surfaces as: failed lots, supplier surprises, validation re-runs, supply-chain risk.
Integral Sealing Ridge
Most diaphragm valves place the primary seal on the diaphragm itself · which traps process fluid and forces the diaphragm to seal and flex at once. Aquasyn moves the seal to the body, machined into a single 5-axis pass, finished to 10–25Ra.
Eliminates entrapment between diaphragm and body, seal drift, extractables risk, and diaphragm double-duty · the diaphragm flexes, the body seals.
Design integrity
Blank-sheet engineering for hygienic purpose. Tork-Tite® feet, integral sealing ridge, precision-molded diaphragm.
Build quality
Consistent in-house manufacturing. One workshop, one engineering team, full documentation traceability on every part.
"I only buy Aquasyn because the quality is like no other."
Proven over thirty years
One founder, one workshop, one engineering team since 1996. The proof is in the fielded equipment, the patents, and the institutions that documented the work.
Founder continuity · single Carson City workshop · 316L stainless, Hastelloy, AL-6XN, titanium · documentation traceable on every part.
Two brands. Aligned engineering. One thirty-year story.
In 2026, Aquasyn and Alphinity aligned operationally. Aquasyn engineered in Carson City, Nevada · Alphinity split across Estonia, Europe and Carson City, Nevada. Shared engineering depth, complementary roadmaps. The catalog you're holding stays Aquasyn · stainless heritage, the components on the spec for thirty years. Alphinity covers what comes next: single-use components, fragile processes, intensified processing.
Stainless heritage · multi-use
Diaphragm valves, ARTēVA® pinch valves, sample and bleed valves, tank bottom, Zero Static, custom fabrication. The trust signal procurement and QA recognize. American-made, on the spec for thirty years.
Single-use
Single-use components and systems for fragile processes, intensified processing, and scale-up. The forward voice on the science. Pixer® positive displacement diaphragm pumps, VannX™ motorized diaphragm valves, Vannefold™ manifolds, TFFi™.
The Alphinity portfolio
Two-Way Valves
A standard diaphragm valve, redesigned for less maintenance, longer diaphragm life, and an environment where contamination can ruin millions of dollars of pharmaceuticals. US-manufactured, standard and custom, stocked in the USA for over 30 years.
For complete ordering, configure at aquasyn.com/configure · legend on p. 19
Configurations available with manual, pneumatic, or eMaxion actuation; standard or block body; optional zero-static, GMP, or sterile-access port arrangements.
Standard features
Tork-Tite® Feet · a hard physical stop
When an operator tightens a manual valve, it is easy to over-tighten and crush the EPDM or PTFE diaphragm. The Tork-Tite feet act as a hard physical stop · the handwheel turns until the feet make metal-to-metal contact with the valve block, compressing the diaphragm by the exact right amount every time. Full details p. 17
Two-Way Variants & Multi-Port Diverters
Variants on the standard two-way diaphragm body · Valbow® integrated valve-elbow, Tee Body 3-way, and multi-port diverter assemblies. Same Tork-Tite® bonnet interface, same diaphragm options, same actuation choices · different process geometries solved at the body.
Valbow® · integrated valve-elbow
A valve and an elbow, machined as a single body. Eliminates the fitting that traditional installations require between a 2-way valve and a 90° turn · saves the weld, the centerline real estate, and the leak path. Originally engineered for the Sample Bottle Assembly (p. 13) where the integrated geometry tightens dimensions and removes a validation point · now also specified into tight-clearance skid layouts, point-of-use installations, and custom hybrid configurations.
Tee Body · 3-way
A 3-way diaphragm valve machined into a single tee-shaped body. One diaphragm seals two flow paths in one assembly · cuts the fitting count, the leak paths, and the centerline distance when a transfer, divert, or branch point would otherwise need two separate valves welded back-to-back. Same Tork-Tite® bonnet, same diaphragm compounds, same actuation options as the standard two-way line.
Multi-Port Diverters · 3 / 4 / 5-way
Multi-combination diverter-style diaphragm valves · a cost-effective answer to overcrowding in complex piping layouts. Same quality customers expect from the rest of the Aquasyn line, machined into a block geometry that combines 3, 4, or 5 flow paths in a single body. Available in horizontal and vertical placements, actuated or manual, with maximum drainability built into the geometry.
All variants share the standard two-way body materials, surface finishes, diaphragm compounds, and actuation options (p. 05, p. 09). Configure at aquasyn.com/configure · part-number legend on p. 19.
Diaphragm materials
All Aquasyn diaphragms are precision-molded to tight tolerances, machined from approved compounds, and shipped with full lot traceability and Certificates of Conformance.
Diaphragm materials
| Material | Best for | Avoid for |
|---|---|---|
| EPDM | WFI, water, broad-pH hygienic, steam & CIP/SIP | Aggressive solvents, mineral oils |
| PTFE-faced / EPDM laminate (TFM 1700) | Aggressive chemistries, broad chemical compatibility | High-frequency cycling under high pressure |
| Silicone | High-temp service, FDA food and pharma contact | Solvent and hydrocarbon service |
| Viton (FKM) | Solvent service, low extractables, hydrocarbons | Strong amines and ketones |
| Nominal size | Manual | Pneumatic |
|---|---|---|
| ¼" – ½" | 145 PSI | 145 PSI |
| ¾" | 145 PSI | 145 PSI |
| 1" | 145 PSI | 145 PSI |
| 1½" | 145 PSI | 145 PSI |
| 2" | 145 PSI | 145 PSI |
| 2½" – 4" | 101 PSI | 101 PSI |
Ratings at 68°F ambient. Derate per the temperature-pressure curve for elevated service.
Continuous-service envelopes. Peak / SIP cycles tolerated above range; consult engineering.
| Process media | EPDM | PTFE/EPDM | Silicone | Viton |
|---|---|---|---|---|
| Water for Injection (WFI) | A | A | A | B |
| Pure steam (SIP, 250°F) | A | A | B | B |
| Sodium hydroxide 1–5% | A | A | B | X |
| Nitric acid 10% | B | A | X | A |
| Acetic acid (dilute) | B | A | B | X |
| Ethanol / IPA | A | A | A | A |
| Buffer (PBS, TRIS, citrate) | A | A | A | B |
| Hydrocarbons (mineral oil) | X | A | X | A |
| Hydrogen peroxide (vaporized) | B | A | B | B |
| Solvent (acetone, MEK) | X | A | X | X |
| Phosphoric acid 10% | A | A | B | A |
| Cell culture media (mAb, CGT) | A | A | A | B |
Indicative only. Verify with extractables data, full process chemistry, temperature, and cycle profile. Engineering reviews critical applications on request.
- USP Class VI · plastic component biological reactivity
- FDA Title 21 CFR Part 177.2600 · food contact, extractables passed
- ASME BPE-2024 · hygienic process equipment
- 3-A Sanitary Standard · 53-06 sanitary fittings
- EN 10204 3.1 · Mill Test Report on body bar stock
- cGMP traceability · lot ID, heat number, machine, operator
Molded in the open position for long service life. Paired with Tork-Tite® feet (p. 16) for controlled compression. Replacement diaphragms stocked for every standard size. Sample-bottle refurbishment available.
Manual Actuation · Bonnet Assemblies
Engineered for long, trouble-free service. Every internal part machined to exacting tolerances. Tork-Tite® feet on every corner and compressor hold the diaphragm in a fixed, repeatable position for zero-leakage closure · the same bonnet architecture across the manual, pneumatic, and eMaxion™ electric lines.
Engineered features
| Travel | Less than 1 turn fully open to closed |
| Closure | Tork-Tite® feet · zero-leakage seat |
| Compressor | Matches weir · no diaphragm crush |
| Travel stops | Fixed · repeatable run to run |
| Handwheel | Plastic · autoclavable · color-coded |
| Internals | 316L · no zinc-plated hardware |
| Lubrication | Factory-lubricated for life |
| Diaphragm change | Field-replaceable · no special tools |
| Cycle life | 10,000+ cycles |
| Interface | Common across manual · pneumatic · electric |
Three configurations
The workhorse
O-ring sealed
Submersible
Order handles in a range of colors to differentiate lines, services, or operators at a glance. Reduces the chance of cross-line operation on busy skids.
Padlock-ready caps for lockout / tagout compliance on critical isolation points. Specify per valve or across a full set during ordering.
Pneumatic & Electric Actuation
Two actuation paths · one shared Tork-Tite® bonnet interface. Pneumatic for facilities with compressed-air infrastructure and fail-safe on/off duty. eMaxion™ electric for modulating control and signal-cable integration.
Pneumatic Actuation
| Power source | Compressed air · 60–100 PSI supply |
| Operation modes | Spring-return (N/O · N/C) · double-acting |
| Housing | Performance plastic · precision stainless internals |
| Modulating | Electro-pneumatic positioner · closed-loop feedback |
| Mounting | NAMUR adaptor · banjo-mount solenoid |
| Limit switches | Mechanical · inductive · intrinsically-safe |
| Travel stops | Integral controlled · repeatable run to run |
| Interface | Common Tork-Tite® bonnet · retrofits manual |
Best when: compressed-air infrastructure is already in place, fail-safe positioning is required, or duty is high-cycle on/off.
eMaxion™ Electric Actuation
| Power | 24 V DC · no compressed air |
| Motion | Direct-drive micro-stepping · 1000s of steps |
| Response time | Milliseconds · independent of supply pressure |
| Modulation accuracy | ±0.7 PSI (±0.05 bar) |
| Feedback | Continuous encoder · closed-loop · actual position |
| Status indicator | Integrated visual on/off · readable at a glance |
| Live data stream | Position · torque · current |
| Connectivity | M12 connector · Pharma 4.0 ready |
| Environmental | IP65 protection |
| Integration | ISA-88 · predictive maintenance · e-records |
| Order code | EM1 · legend p. 19 |
Best when: modulating control matters, cleanrooms can't tolerate compressed-air infrastructure, or the process roadmap blends stainless multi-use with single-use bioprocess.
ARTēVA® Pinch Valves
A pinch valve line where the mechanism and the flow path are decoupled. Reusable 316L stainless pinch head · replaceable tubing flow path. Same patented Tork-Tite® bonnet interface as the diaphragm line · drops on manual, pneumatic, and eMaxion™ electric actuators.
Three actuation modes
Manual · Pneumatic · Electric
| Attribute | Manual | Pneumatic | eMaxion™ Electric |
|---|---|---|---|
| Power source | Operator · handwheel | Compressed air · 60–100 PSI | 24 V DC · single cable |
| Pinch force | Operator-set | Air-pressure proportional | Motor-controlled · repeatable |
| Modulation | Manual position | Positioner option · closed-loop | Native · ±0.7 PSI · encoder |
| Cycle service | Low-cycle · maintenance | High-cycle on/off | High-cycle modulating |
| Feedback | Stem position · direct visual | Limit switches · IS option | Encoder · integrated visual on/off |
| Cleanroom | Silent | Air exhaust noise | Silent · no air handling |
| Best for | Setup · sampling · service points | Harvest lines · transfer · CIP | Perfusion · fill-finish · Pharma 4.0 |
| Order code | 16 | 18 N/O · 19 N/C | Confirmed on quote |
| Tubing ID range | ¼" – 1" |
| Tubing materials | Silicone · TPE · braided · reinforced |
| Tubing source | All major vendors · no vendor lock-in |
| Pinch head | 316L stainless · encapsulated |
| Pinch design | Central · minimizes wear on tubing and body |
| Cycle life | 10,000+ closure cycles · maintained reliability |
| Continuous run | 3+ days · continuous bioprocessing rated |
| Pressure (eMaxion) | 87 PSI (6 bar) with rated tubing |
| Temperature | Per tubing · silicone −4°F to +248°F |
Sterile Access / GMP Combinations
Any conceivable valve-to-valve or valve-to-fitting configuration in the industry · traditional valve-to-valve and block-body styles. Stocked components plus dedicated in-house machining, internal and external polishing, and electropolishing for extremely fast lead times. Fabrication, welding, and polishing exhibit inherent quality to meet and exceed industry standards for drainability, dead legs, surface finish, and performance.
Engineered features
- Minimized dead legs
- Maximum drainability
- Configured to specific system layout
- Selection sheet available
- Stocked components enable "made-to-order" assemblies
- Short lead times
Block-body machining
Configure at aquasyn.com/configure (part-number legend on p. 19). Certifications, materials, and compliance detailed on p. 07.
Zero Static Tee · Points of Use
Block-body design with the tightest bend radii in the industry. True zero-static geometry, completely drainable, fully machined from a single block. Integrated sampling and custom options available across both lines.
Zero Static Tee bodies
A hygienic tee where the side branch is machined directly into a single block, eliminating the dead leg a traditional welded tee creates. Used wherever a process line needs a sample port, drain, vent, or transfer takeoff without the bacterial risk of stagnant fluid · WFI and PW loops, CIP/SIP headers, bioreactor feed and return, fill-finish skids.
- True zero-static design
- Fully machined from block
- Completely drainable
- Readily cleanable exterior · sloped and radiused
- Integrated sampling valves available
- Made-to-order from stocked components
Points of Use
The drop-off valve from a recirculating clean utility loop (WFI, PW, clean steam) that delivers fluid to a fill station, sampling point, or equipment hookup. The U-shaped block keeps the main loop flowing past the valve · zero stagnant fluid between draws, fully drainable between uses. P1 / P2 / P3 orientations cover the standard piping geometries.
- State-of-the-art block-body design
- Tightest bend radii in the industry
- Minimized footprint · compact centerlines
- Low pressure drop · high Cv
- Integrated sampling valves and custom options
- P1 · P2 · P3 orientations · ½"–2"
Sampling solutions
Sample/bleed valves with four orientations on one mechanism, and the industry-standard re-usable sample bottle assembly built around the integrated Valbow® · machined from 316L bar stock with no castings.
Sample / Bleed Valves
A small-bore valve teed off a main process line to draw representative samples or bleed gas during fill, with a rising-stem TFM tip that seals positively against a 316L body. Used at bioreactor sample ports, WFI loop takeoffs, fill-finish skids, and anywhere a closed sterile boundary needs controlled access for QC or process monitoring.
| Orifice | 0.370" std · custom |
| Body | 316L · Hastelloy® · AL-6XN® |
| Finish | 5Ra–25Ra · EP and mechanical |
| Seal | PTFE/TFM (P) · EPDM (E) |
| Operation | Manual · pneumatic · eMaxion™ |
| Pressure | 145 PSI at 68°F · per body |
- Rising-stem TFM seal tip · positive metal-to-metal stop
- Less than one turn fully open to closed
- USP Class VI seal · FDA 21 CFR 177.2600
- Integral Sealing Ridge on body (see p. 16) · no entrapment
- SIP and CIP service · autoclavable bonnet
- Machined from 316L bar stock · no castings
Sample Bottle Assembly
A re-usable glass-bottle sampling system built around the Valbow® integrated valve-elbow on the cap. Bench-side, the operator opens the Valbow to draw a representative sample without breaking the sterile boundary or contaminating the bottle interior. Used at bioreactor and WFI sample points across pharma and biotech · the industry-standard alternative to single-use sample bags where lifecycle cost matters.
- Sizes 250 mL and 500 mL · other sizes on request
- Color-coded caps for sample identification
- Fully autoclavable · Schott Duran borosilicate
- Integrated Valbow® valve · see p. 06
- Inspection & refurbishment service
- Lower TCO than single-use sample bags
| Size | Common use |
|---|---|
| 250 mL | Bioreactor process |
| 500 mL | WFI / utility |
Tank Bottom Valves
The Aquasyn two-way diaphragm valve, configured at the vessel-bottom drain point. Two styles · Welded Flange and Tri-Tank · sized to the vessel, with the weir face moved close to the connection to eliminate stagnant fluid. Machined from 316L bar stock.
Sits at the lowest point of a tank or vessel to drain product, recover CIP rinse, or harvest a batch. The drain-optimized geometry eliminates the dead leg a standard tee or flush valve creates · critical wherever residual fluid would breed bacteria or contaminate the next batch. Used on bioreactors, fermenters, hold tanks, CIP skids, and any vessel that needs to empty cleanly between runs.
Two styles
Foundational Aquasyn tank-bottom design, re-engineered into a more compact unit. Weir face positioned closer to the weld flange · stagnant fluid at the vessel bottom is eliminated.
Same drain-optimized geometry, terminated in a tri-clamp connection instead of a weld. The right choice for vessels that strip and clean regularly · or where the valve must come off without breaking the weld.
Specifications & drain geometry
| Style | Welded Flange (¼"–4") · Tri-Tank (¼"–4") |
| Body material | 316L · Hastelloy® · AL-6XN® · Titanium |
| Surface finish | 5Ra–25Ra · EP and mechanical |
| Connections (Tri) | Hygienic clamp · butt weld · orbital weld |
| Diaphragm | EPDM · TFM · PTFE-EPDM laminate |
| Operation | Manual · pneumatic · eMaxion™ electric |
| Pressure | 145 PSI (10 bar) at 68°F · per body |
| Etched marks | Drain-angle alignment on every end connection |
Geometric angles at which the body achieves complete gravity drainage. Etched on every end connection so installers verify orientation by eye.
| Nominal size | Optimum angle |
|---|---|
| ¼" | 41° |
| ⅜" | 30° |
| ½" | 25° |
| ¾" | 18° |
| 1" | 30° |
| 1½" | 25° |
| 2" | 23° |
Custom Fabrication
Application-specific assemblies for the case where a standard catalogue size or configuration won't do the job. Aquasyn's forte since 1996. Sole-source responsibility from drawing to inspected assembly.
Capabilities
| CAE design | 3D SolidWorks & AutoCAD · detailed drawings |
| Machining | State-of-the-art 5-axis centers |
| Welding | Orbital · TIG · skilled craft persons |
| Polishing | Internal · external · electropolish (EP10) |
| Materials | 316L · Hastelloy® · AL-6XN® · Titanium · exotic |
| Turnaround | Concept → drawing → production · in-house |
Custom valves
Special end connections, custom orientations, and hybrid bodies that combine patented Aquasyn mechanisms in non-standard layouts. Bespoke valve assemblies for unusual process geometries · what the engineering team has built more of than anything else in this catalogue. Send the sketch · engineering picks it up from there.
Other recurring custom lines
Four patents · four mechanisms
Aquasyn's patents are not marketing decoration. Each one solves a specific failure mode in hygienic process that the industry-adapted alternative does not · prototyped, fielded, and refined in the Carson City workshop.
Precision-machined contact points on the bonnet corners. Match the weir profile to a single-thousandth-inch tolerance · fixed diaphragm position, zero-leakage closure, less than one turn open-to-closed.
Sealing ring machined into the body in a single 5-axis pass, not on the diaphragm. Zero entrapment, repeatable flow without seal drift, longer diaphragm life · the diaphragm flexes, the body seals.
A valve and an elbow machined as a single body. Created when a customer brought Aquasyn a request no one else in the industry wanted to pursue · re-thinks how valves and elbows share a body. Standard on every Sample Bottle Assembly (p. 13) · also specified into tight-clearance skid layouts, points of use, and custom hybrid configurations. Full product page on p. 06.
Direct-drive 24 V DC motorized actuator engineered for biopharm. No compressed air, no FRL, no solenoid. Encoder feedback continuously reports actual position. Micro-stepping motion delivers ±0.7 PSI modulation accuracy and millisecond response. One actuator drops onto three valve platforms · Aquasyn diaphragm, ARTēVA® pinch, Alphinity VannX™ single-use. Full spec on p. 09.
All Aquasyn patents are held by Aquasyn LLC. Patent numbers and filing dates available on request.
Flow Coefficients & Self-Drain
Cv curves and self-drain geometry for the standard two-way valve family. Use these to size a valve against a specified flow rate at a given pressure drop, and to confirm that an installed valve will self-drain at the orientation it is being installed.
Cv values · ±10% tolerance
| % Open | ½" | ¾" | 1" | 1½" | 2" |
|---|---|---|---|---|---|
| 10% | 0.5 | 1.1 | 1.4 | 4.0 | 7.6 |
| 20% | 1.0 | 2.0 | 2.1 | 9.3 | 16.5 |
| 30% | 1.4 | 3.7 | 4.3 | 14.2 | 22.3 |
| 40% | 1.7 | 4.3 | 6.9 | 18.9 | 27.5 |
| 50% | 1.9 | 4.8 | 8.8 | 22.0 | 35.6 |
| 60% | 1.9 | 5.0 | 10.9 | 25.0 | 43.5 |
| 70% | 2.0 | 5.0 | 13.1 | 28.9 | 48.2 |
| 80% | 2.3 | 5.4 | 14.2 | 34.0 | 54.3 |
| 90% | 2.6 | 6.0 | 15.6 | 37.8 | 58.6 |
| 100% | 3.0 | 6.8 | 17.3 | 43.6 | 66.0 |
Optimum self-drain angles
| Size | Angle | Size | Angle |
|---|---|---|---|
| ¼" | 41° | 1" | 30° |
| ⅜" | 30° | 1½" | 25° |
| ½" | 25° | 2" | 23° |
| ¾" | 18° | All standard 2-way bodies | |
Etched alignment marks on every end connection allow installation at the correct angle for full gravity drainage. Verify orientation against the body markings before tack-welding into the line. See p. 14 (Tank Bottom) for drain geometry on tank-bottom bodies.
Documentation Packages
Every Aquasyn part ships with documentation procurement, QA, and validation engineers can actually use. Defensible under audit, traceable to heat number, machinist, inspector, and date. The standard package covers the audit case · additional documents available on request for validation, change-control, and customer-specific quality systems.
- Material Test Reports (MTRs) · all wetted-surface materials
- Certificates of Conformance · diaphragms
- Surface finish profilometer readings · critical surfaces
- ASME BPE-2024 chemistry compliance
- Lot traceability · every component
- Weld logs · fabricated assemblies
- Electropolish records
- FAT / SAT documentation
- Validation pack templates (IQ / OQ alignment)
- Customer-specific change-control
- Audit support · quality-system documentation
Engineering and QA teams are accessible to specifiers directly · not through a sales filter. Material questions, deviation reports, and validation alignment go straight to the engineer who built the part.
Full certification list (USP Class VI, FDA 21 CFR 177.2600, ASME BPE-2024, 3-A Sanitary, EN 10204 3.1, cGMP) detailed on the diaphragm-materials page · see p. 07.
Configure · Specify · Request a quote
Configure your valve at the online configurator · valid combinations only, live pricing, custom routes straight to engineering. This page is the legend for reading a part number you already have on a quote or PO.
Scan the QR or type the URL. Tank Bottom, Sample/Bleed, multi-bonnet, exotic alloys all configurable.
Talk to the team
behind the part.
Configure online for standard builds. For custom assemblies, large-volume orders, and engineering questions · the team below answers directly.
Business development
/company/aquasyn · Part of the Alphinity family · alphinity.io
Better by design.